At least 80% of Chronic
Wounds Contain Biofilm

Biofilm is associated with delayed wound healing and other negative wound healing outcomes. Solutions for the elimination of biofilm have demonstrated significant challenges, due in part to the complexity of the biofilm structure.

Synergy of the components was determined
P. aeruginosa
P. aeruginosa
MRSA
MRSA

Pseudomonas aeruginosa and Methicillin-resistant Staphylococcus aureus (MRSA) are commonly found in biofilms of chronic wounds.

PHMB, Vicinal Diols and EDTA All Have Separate Functions To Create Disruption of the Biofilm Extracellular Polymeric Substances (EPSs)

PHMB aggregates and clumps various EPS polymers

PHMB aggregates and clumps various EPS polymers

EDTA separates and pulls apart the EPS matrix

EDTA separates and pulls apart the EPS matrix

Vicinal diols dissolve or swell the humic substances and lipids in the EPSs

Vicinal diols dissolve or swell the humic substances and lipids in the EPSs

Chart

Synergy of the components was determined by Kull equation analysis based on MBEC peg biofilm assay results utilizing mono-species P. aeruginosa and S. aureus (MRSA) biofilms.

The complete BIAKŌS™ ANTIMICROBIAL SKIN AND WOUND CLEANSER reduced the viability of P. aeruginosa mono-species biofilms by more than 5 logs and eliminated Methicillin-resistant Staphylococcus aureus (MRSA).

DOWNLOAD the complete paper - Synergistic Effect and Antibiofilm Activity of a Skin and Wound Cleanser (Salamone et. al) Wounds 2020.

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Synergistic Effect and Antibiofilm Activity of a Skin and Wound Cleanser

Ann Beal Salamone, MA1; Joseph C. Salamone, PhD1; Rebecca Erin McMahon, PhD; Suprena Poleon, BS; Nina Bionda, PhD; and Peter D’Arpa, PhD Wounds 2020;32(8):208–216. Epub 2020 May 7

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