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Comparison of the Rapid Bactericidal Efficacy of Commercially Available Surgical Solutions

Authors: Larry Estlack, Rebecca McMahon, PhD, Nina Bionda, PhD 

Reported here is a comparative assessment of the in vitro rapid bactericidal efficacy of a panel of nine commercially available irrigation solutions using short (60 seconds) contact time. The study was performed using two representative species of bacteria – Gram-positive methicillin-resistant Staphylococcus aureus (MRSA) and Gram-negative Pseudomonas aeruginosa. The irrigation solutions evaluated in the study involved an array of antimicrobial technologies and preservatives, including acids, surfactants, chlorhexidine gluconate (CHG), benzalkonium chloride (BZK), polyhexamethylene biguanide (PHMB) alone and in synergy with other additives, and povidone iodine (PI).

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Nina assumed the role of Director of Research at Rochal Technologies, the Research and Development arm of Sanara MedTech, in September 2022. In this position, she bears the responsibility of orchestrating the conception and execution of critical internal and external studies vital for advancing surgical and wound care products. Dr. Bionda holds a BS degree in Biochemical Engineering from University of Zagreb and a PhD in Chemistry from Florida Atlantic University. Following her postdoctoral training at the University of Rochester, she spent seven years at a pre-clinical Contract Research Organization (CRO) specializing in the comprehensive evaluation of diverse medical devices. During this time, she led projects ranging from essential R&D support to generating pivotal data for FDA submissions and post-market studies.

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